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IE doesn't support PDF files natively, you require a plugin (most commonly from Adobe) to open them. Chrome and Firefox have native renderers.
These are the two possibilities that come to the top of my mind...
1. The PDF is too large to load via the IE->Plugin path and is loading in Chrome or Firefox because of the lower resource requirements they require.
2. The PDF is loading but is just so large that it's still loading by the time you give up, it looks blank because the plugin is attempting to load the entire file into memory before rendering any pages. Neither Chrome or Firefox require the entire PDF be loaded before they start rendering so it just seems faster.
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